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Article

Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature

28 May 2009

Abstract excerpt

We performed in vivo phage display in the stroke prone spontaneously hypertensive rat, a cardiovascular disease model, and the normotensive Wistar Kyoto rat to identify cardiac targeting peptides, and then assessed each in the context of viral gene delivery. We identified both common and strain-selective peptides, potentially indicating ubiquitous markers and those found selectively in dysfunctional...

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PMID: 19481546
DOI: 10.1016/j.febslet.2009.05.037

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