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Article

Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2

1 Jan 2009

Abstract excerpt

BACKGROUND: Recent evidence suggests that several human cancers are capable of uncoupling of mitochondrial ATP generation in the presence of intact tricarboxylic acid (TCA) enzymes. The goal of the current study was to test the hypothesis that ketone bodies can inhibit cell growth in aggressive cancers and that expression of uncoupling protein 2 is a contributing factor. The proposed mechanism involves inhibition...

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PMID: 19480693
DOI: 10.1186/1475-2867-9-14

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