Article
The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
Obesity (Silver Spring, Md.) - 1 Dec 2009
Zhao Jianhua, Bradfield Jonathan P, Li Mingyao, Wang Kai, Zhang Haitao, Kim Cecilia E, Annaiah Kiran, Glessner Joseph T, Thomas Kelly, Garris Maria, Frackelton Edward C, Otieno F George, Shaner Julie L, Smith Ryan M, Chiavacci Rosetta M, Berkowitz Robert I, Hakonarson Hakon, Grant Struan F A
Abstract excerpt
The prevalence of obesity in children and adults in the United States has increased dramatically over the past decade. Besides environmental factors, genetic factors are known to play an important role in the pathogenesis of obesity. A number of genetic determinants of adult BMI have already been established through genome-wide association (GWA) studies. In this study, we examined 25 single-nucleotide...
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