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Article

Improving the species cross-reactivity of an antibody using computational design.

Bioorganic & medicinal chemistry letters - 15 Jul 2009

Farady Christopher J, Sellers Benjamin D, Jacobson Matthew P, Craik Charles S

Abstract excerpt

The high degree of specificity displayed by antibodies often results in varying potencies against antigen orthologs, which can affect the efficacy of these molecules in different animal models of disease. We have used a computational design strategy to improve the species cross-reactivity of an antibody-based inhibitor of the cancer-associated serine protease MT-SP1. In silico predictions were tested in vitro,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19477127
DOI: 10.1016/j.bmcl.2009.05.005
PMCID: PMC2724971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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