Article
DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm.
European journal of human genetics : EJHG - 1 Dec 2009
Kobayashi Hisato, Hiura Hitoshi, John Rosalind M, Sato Akiko, Otsu Eiko, Kobayashi Naoko, Suzuki Rei, Suzuki Fumihiko, Hayashi Chika, Utsunomiya Takafumi, Yaegashi Nobuo, Arima Takahiro
Abstract excerpt
There is an increased prevalence of imprinting disorders, such as Beckwith-Wiedemann syndrome, associated with human assisted reproductive technologies (ART). Work on animal models suggests that in vitro culture may be the source of these imprinting errors. However, in this study we report that, in some cases, the errors are inherited from the father. We analyzed DNA methylation at seven autosomal imprinted loci...
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