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Article

Immune tolerance induced by platelet-targeted factor VIII gene therapy in hemophilia A mice is CD4 T cell mediated.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2017

Chen Y, Luo X, Schroeder J A, Chen J, Baumgartner C K, Hu J, Shi Q

Abstract excerpt

Essentials The immune response is a significant concern in gene therapy. Platelet-targeted gene therapy can restore hemostasis and induce immune tolerance. CD4 T cell compartment is tolerized after platelet gene therapy. Preconditioning regimen affects immune tolerance induction in platelet gene therapy. SUMMARY: Background Immune responses are a major concern in gene therapy. Our previous studies demonstrated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28799202
DOI: 10.1111/jth.13800
PMCID: PMC5630523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Immune tolerance induced by platelet-targeted factor VIII gene therapy in hemophilia A mice is CD4 T cell mediated.PMID 28799202Read ↗

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