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Article

Accumulation of large protein fragments in prematurely senescent ARPE-19 cells.

Investigative ophthalmology & visual science - 1 Oct 2009

Liao Wei-Li, Turko Illarion V

Abstract excerpt

PURPOSE: Senescence of retinal pigment epithelial (RPE) cells is a crucial event in the pathogenesis of age-related macular degeneration (AMD). This study was designed to improve the understanding of proteomic changes that underlie RPE senescence. Specifically, the levels of several protein fragments in prematurely senescent ARPE-19 cells were quantitatively compared with those in control cells. METHODS:...

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Share to Cellular Senescence
Share to Chromatography, Liquid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Gel, Two-Dimensional

Share to Pyruvate Kinase

Share to Retinal Pigment Epithelium

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Share to Triose-Phosphate Isomerase

Source

Identifiers

PMID: 19458325
DOI: 10.1167/iovs.09-3671

Genes

RPE
GAPDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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