Article
Evaluation of VCH-759 monotherapy in hepatitis C infection.
Journal of hepatology - 1 Jul 2009
Cooper Curtis, Lawitz Eric J, Ghali Peter, Rodriguez-Torres Maribel, Anderson Frank H, Lee Samuel S, Bédard Jean, Chauret Nathalie, Thibert Roch, Boivin Isabel, Nicolas Olivier, Proulx Louise
Abstract excerpt
BACKGROUND/AIMS: VCH-759 is a non-nucleoside inhibitor of HCV RNA-dependent polymerase with sub-micromolar IC(50) values versus genotype 1a/1b replicons. METHODS: The antiviral activity, pharmacokinetics and tolerability of VCH-759 administered as monotherapy for 10 days with a 14 day follow-up p...
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