Human papillomavirus research: Do we still need animal models?

Abstract excerpt

Dear Sir, Papillomaviruses (PVs) are nonenveloped DNA viruses that are tumorigenic to humans and numerous animal species.1 Human PVs (HPVs) are of great medical importance because high-risk HPV types, primarily HPV-16 and HPV-18, are the causative agents of cancer. The most important and best documented HPV-associated cancer is cervical carcinoma, with which HPV is associated in more than 90% of cases.2-4 Much of...

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