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Article

Analogs of MK-499 are differentially affected by a mutation in the S6 domain of the hERG K+ channel.

Biochemical pharmacology - 15 May 2009

Karczewski Jerzy, Wang Jixin, Kane Stefanie A, Kiss Laszlo, Koblan Kenneth S, Culberson J Christopher, Spencer Robert H

Abstract excerpt

Drug-induced long QT syndrome has been principally ascribed to block of the cardiac hERG K(+) channel. Methanesulfonanilides, such as MK-499, E-4031 and dofetilide, are potent hERG antagonists that likely bind along the S6 helix within the inner vestibule of the pore. To further investigate these...

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Identifiers

PMID: 19426697
DOI: 10.1016/j.bcp.2009.02.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19426697-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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