Native secondary structure topology has near minimum contact energy among all possible geometrically constrained topologies.

Abstract excerpt

Secondary structure topology in this article refers to the order and the direction of the secondary structures, such as helices and strands, with respect to the protein sequence. Even when the locations of the secondary structure Calpha atoms are known, there are still (N!2(N))(M!2(M)) different possible topologies for a protein with N helices and M strands. This work explored the question if the native topology...

Topics

• Mutation
• Protein Conformation
• Protein Folding
• Protein Structure, Secondary
• Proteins
• Thermodynamics