Article
Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs.
Neurology - 5 May 2009
Di Lorenzo C, Pierelli F, Coppola G, Grieco G S, Rengo C, Ciccolella M, Magis D, Bolla M, Casali C, Santorelli F M, Schoenen J
Abstract excerpt
OBJECTIVES: In migraine, an interictal reduction of mitochondrial energy metabolism and a preventive effect of high-dose riboflavin were reported. To explore the relation between the two, we tested if the therapeutic response to riboflavin is associated with specific mitochondrial DNA (mtDNA) haplogroups. We focused our attention on haplogroup H, which is known to differ from others in terms of energy metabolism....
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