The candidate gene approach to the diagnosis of monogenic disorders.

doi:10.1159/000192431

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The candidate gene approach to the diagnosis of monogenic disorders.

Hormone research - 1 Apr 2009

Dattani Mehul T

Abstract excerpt

The genetic basis of many human diseases has been elucidated by the candidate gene approach. Mouse models of human disease, whether naturally occurring or derived by transgenesis, have enabled a number of disease genes to be identified. Such approaches have formed the basis of the identification of candidate genes implicated in hypothalamo-pituitary development. Nevertheless, significant differences exist between...

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