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Article

Structure-activity relations of nanolipoblockers with the atherogenic domain of human macrophage scavenger receptor A.

Biomacromolecules - 8 Jun 2009

Plourde Nicole M, Kortagere Sandhya, Welsh William, Moghe Prabhas V

Abstract excerpt

Oxidized low density lipoprotein (oxLDL) uptake by macrophages is mediated by scavenger receptors and leads to unregulated cholesterol accumulation. Micellar nanolipoblockers (NLBs) consist of alkyl chains and polyethylene glycol on mucic acid. NLBs functionalized with anionic groups inhibit oxLDL uptake via the scavenger receptor A (SR-A). Molecular modeling and docking approaches were used to understand the...

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Identifiers

PMID: 19405544
DOI: 10.1021/bm8014522
PMCID: PMC2716033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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