Article
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection.
The New England journal of medicine - 30 Apr 2009
Hézode Christophe, Forestier Nicole, Dusheiko Geoffrey, Ferenci Peter, Pol Stanislas, Goeser Tobias, Bronowicki Jean-Pierre, Bourlière Marc, Gharakhanian Shahin, Bengtsson Leif, McNair Lindsay, George Shelley, Kieffer Tara, Kwong Ann, Kauffman Robert S, Alam John, Pawlotsky Jean-Michel, Zeuzem Stefan
Abstract excerpt
BACKGROUND: In patients with chronic infection with hepatitis C virus (HCV) genotype 1, treatment with peginterferon alfa and ribavirin for 48 weeks results in rates of sustained virologic response of 40 to 50%. Telaprevir is a specific inhibitor of the HCV serine protease and could be of value in HCV treatment. METHODS: A total of 334 patients who had chronic infection with HCV genotype 1 and had not been...
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