Article
Combination therapy with telaprevir for chronic hepatitis C virus genotype 1 infection in patients with HIV: a randomized trial.
Annals of internal medicine - 16 Jul 2013
Sulkowski Mark S, Sherman Kenneth E, Dieterich Douglas T, Bsharat Mohammad, Mahnke Lisa, Rockstroh Jürgen K, Gharakhanian Shahin, McCallister Scott, Henshaw Joshua, Girard Pierre-Marie, Adiwijaya Bambang, Garg Varun, Rubin Raymond A, Adda Nathalie, Soriano Vincent
Abstract excerpt
BACKGROUND: Telaprevir (TVR) plus peginterferon-α2a (PEG-IFN-α2a) and ribavirin substantially increases treatment efficacy for genotype 1 chronic hepatitis C virus (HCV) infection versus PEG-IFN-α2a-ribavirin alone. Its safety and efficacy in patients with HCV and HIV-1 are unknown. OBJECTIVE: To assess the safety and efficacy of TVR plus PEG-IFN-α2a-ribavirin in patients with genotype 1 HCV and HIV-1 and to...
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