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Article

Rational design of an organometallic glutathione transferase inhibitor.

Angewandte Chemie (International ed. in English) - 1 Jan 2009

Ang Wee Han, Parker Lorien J, De Luca Anastasia, Juillerat-Jeanneret Lucienne, Morton Craig J, Lo Bello Mario, Parker Michael W, Dyson Paul J

Abstract excerpt

Double trouble: A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods.

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Source

Identifiers

PMID: 19396894
DOI: 10.1002/anie.200900185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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