Article
The combination of polymorphisms within MCP-1 and IL-1beta associated with ulcerative colitis.
International journal of immunogenetics - 1 Jun 2009
Li K-S, Wang B-Y, Liu S-Y, Yao S-P, Guo L, Mao D-W
Abstract excerpt
Monocyte chemoattractant protein-1 (MCP-1) is a chemokine involved in monocyte recruitment to sites of inflammation. Raised level of MCP-1 has been widely demonstrated in the intestinal mucosa of patients with ulcerative colitis (UC), suggesting an important role of MCP-1 in the pathogenesis of UC. The -2518A/G polymorphism in the promoter region of MCP-1 gene affecting its transcriptional activation has been...
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