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RNAi screen reveals a role of SPHK2 in dengue virus–mediated apoptosis in hepatic cell lines

16 Nov 2017

Abstract excerpt

Hepatic dysfunction is a feature of dengue virus (DENV) infection. Hepatic biopsy specimens obtained from fatal cases of DENV infection show apoptosis, which relates to the pathogenesis of DENV infection. However, how DENV induced liver injury is not fully understood. In this study, we aim to identify the factors that influence cell death by employing an apoptosis-related siRNA library screening. Our results show...

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PMID: 29145490
DOI: 10.1371/journal.pone.0188121

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