Article
[Effect of sho1 gene of Aspergillus fumigatus on adaptation to osmotic pressure and on sensitivity of antifungal drugs].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences - 18 Apr 2009
Ma Yan, Qiao Jian-jun, Liu Wei, Li Ruo-yu
Abstract excerpt
OBJECTIVE: To construct the sho1 gene mutant of Aspergillus fumigatus, and to investigate the function of sho1 in adaptation to environmental changes. METHODS: Saccharomyces cerivisiae sho1 gene homolog was identified by tblastn searches in A. fumigatus genome database. A PCR fragment, composed of the 5' flanking sequence (approximately 1 kb) of sho1, sho1 ORF, and its 3' flanking sequence (approximately 1 kb),...
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