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West Nile Virus Capsid Degradation of Claudin Proteins Disrupts Epithelial Barrier Function

16 Apr 2009

Abstract excerpt

During acute infection, West Nile virus (WNV) has been reported to infect a variety of cell types in various tissues of both experimentally and naturally infected hosts. Virus infects epithelial cells in the skin, kidney, intestine, and testes, although the importance of these findings is unclear. In the current study, we have observed that WNV infection of kidney tubules in mice coincides with the loss of...

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PMID: 19369347
DOI: 10.1128/jvi.02617-08

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