Article
Platelet GP IIIA polymorphism HPA-1 (PLA1/2) is associated with hypertension as the primary cause for end-stage renal disease in hemodialysis patients from Greece.
In vivo (Athens, Greece) - 1 Jan 2000
Chiras Theodore, Papadakis Emmanuel D, Katopodi Aggeliki, Chatzianesti Efrosini, Fourtounas Kostas, Papakonstantinou Stamatina, Theodoropoulos Ilias, Dakouras Anastasios, Zerefos Nikolas, Valis Dimitrios, Tzanatos-Exarchou Helen
Abstract excerpt
Human platelets carry membrane glycoproteins that control platelet aggregation and activation. A number of clinical studies have suggested that certain polymorphisms of genes encoding these proteins increase the risk for cardiovascular disease. The frequency of gene polymorphisms for the four most common platelet glycoproteins (HPA 1, 2, 3 and 5) was examined and correlated with the primary cause of end-stage...
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