Mechanical signals trigger Myosin II redistribution and mesoderm invagination in Drosophila embryos.

doi:10.1126/scisignal.2000098

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Article

Mechanical signals trigger Myosin II redistribution and mesoderm invagination in Drosophila embryos.

Science signaling - 14 Apr 2009

Pouille Philippe-Alexandre, Ahmadi Padra, Brunet Anne-Christine, Farge Emmanuel

Abstract excerpt

During Drosophila gastrulation, two waves of constriction occur in the apical ventral cells, leading to mesoderm invagination. The first constriction wave is a stochastic process mediated by the constriction of 40% of randomly positioned mesodermal cells and is controlled by the transcription factor Snail. The second constriction wave immediately follows and involves the other 60% of the mesodermal cells. The...

Topics

Animals
Drosophila
Drosophila Proteins
Embryo, Nonmammalian
Genotype
Mesoderm
Models, Biological
Mutation
Myosin Type II
Phenotype
Signal Transduction
Snail Family Transcription Factors
Time Factors
Transcription Factors
Twist-Related Protein 1

Source

Open in PubMed

Identifiers

PMID: 19366994
DOI: 10.1126/scisignal.2000098

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