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Article

Role of extracellular signal-regulated kinase for endothelial progenitor cell dysfunction in coronary artery disease.

Basic research in cardiology - 1 Sept 2009

Friedrich Erik B, Werner Christian, Walenta Katrin, Böhm Michael, Scheller Bruno

Abstract excerpt

In patients with coronary artery disease (CAD), number and function of endothelial progenitor cells (EPCs) are down-regulated. The relevant intracellular signalling mechanisms responsible for dysfunction of EPCs in CAD remain poorly characterized. Our goal was to examine the regulation of ERK-1/2 by SDF-1 and the role of ERK-1/2 for adhesion in EPCs. Western analysis revealed that the chemokine SDF-1 (SDF-1, 100...

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Source

Identifiers

PMID: 19363666
DOI: 10.1007/s00395-009-0022-6

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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