Article
[Molecular mechanisms and correlations of insulin resistance, obesity, and type 2 diabetes mellitus].
Orvosi hetilap - 26 Apr 2009
Winkler Gábor, Cseh Károly
Abstract excerpt
Adipose tissue cells express and secrete numerous proteins influencing the signal transduction pathways of insulin receptor by auto-, para- and endocrine manner. Several cytokines, tumor necrosis factor-alpha and its soluble receptor forms, sTNFR1 and sTNFR2, resistin, retinol-binding protein 4, plasminogen activator inhibitor, lipocain 1 inhibit the signalization of insulin receptor causing insulin resistance in...
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