Article
The serotonin transporter gene and disease modification in psychosis: evidence for systematic differences in allelic directionality at the 5-HTTLPR locus.
Schizophrenia research - 1 Jun 2009
Goldberg Terry E, Kotov Roman, Lee Annette T, Gregersen Peter K, Lencz Todd, Bromet Evelyn, Malhotra Anil K
Abstract excerpt
A 44 base pair insertion ("l")/deletion ("s") polymorphism (called 5-HTTLPR) in the 5' promoter region of the human serotonin transporter gene (SLC6A4) modulates expression and has been associated to anxiety and depressive traits in otherwise healthy individuals. In individuals with psychiatric diagnoses, including schizophrenia, it seems to modulate symptom severity. Thus, it may be a disease modifying gene. In...
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