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Article

Influence of p38MAPK inhibition on IL-1beta-stimulated human chondrocytes: a microarray approach.

International journal of molecular medicine - 1 May 2009

Joos Helga, Albrecht Wolfgang, Laufer Stefan, Brenner Rolf E

Abstract excerpt

Articular chondrocytes respond to extracellular influences by activating signaling pathways which change gene expression. One key signal transduction pathway of inflammatory joint disease is mediated by the p38MAPK which is known to be activated by the pro-inflammatory cytokine IL-1beta. We used the p38MAPK inhibitor SB203580 and a whole human genome microarray in an in vitro inflammation model to identify genes...

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Identifiers

PMID: 19360329
DOI: 10.3892/ijmm_00000181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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