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Article

Neurosphere Formation Is an Independent Predictor of Clinical Outcome in Malignant Glioma

22 Jan 2009

Abstract excerpt

Renewable neurosphere formation in culture is a defining characteristic of certain brain tumor initiating cells. This retrospective study was designed to assess the relationship among neurosphere formation in cultured human glioma, tumorigenic capacity, and patient clinical outcome. Tumor samples were cultured in neurosphere conditions from 32 patients with glioma, including a subpopulation of 15 patients with...

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PMID: 19353526
DOI: 10.1002/stem.15

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