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Article

The ATM regulated DNA damage response pathway as a chemo- and radiosensitisation target

7 Apr 2009

Abstract excerpt

Citicoline (cytidine-5'-diphosphocholine or CDP-choline) is a precursor essential for the synthesis of phosphatidylcholine, one of the cell membrane components that is degraded during cerebral ischemia to free fatty acids and free radicals. Animal studies suggest that citicoline may protect cell membranes by accelerating resynthesis of phospholipids and suppressing the release of free fatty acids, stabilizing...

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PMID: 19351232
DOI: 10.1517/17460440902835475

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