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Article

Mutations in the lamin B1 gene are not present in multiple sclerosis.

European journal of neurology - 1 Apr 2009

Brussino A, D'Alfonso S, Cagnoli C, Di Gregorio E, Barberis M, Padovan S, Vaula G, Pinessi L, Squadrone S, Abete M C, Collimedaglia L, Guerini F R, Migone N, Brusco A

Abstract excerpt

BACKGROUND: Whole gene duplication of the lamin B1 gene (LMNB1), encoding for a protein of the nuclear lamina, causes an adult-onset autosomal dominant leukodystrophy (ADLD). Clinical features of ADLD (onset in adult life, dysautonomic symptoms, followed by pyramidal and cerebellar dysfunctions) partially resemble those of multiple sclerosis (MS), particularly the primary-progressive form. Our aim was to test...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19348623
DOI: 10.1111/j.1468-1331.2009.02536.x

Genes

LMNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mutations in the lamin B1 gene are not present in multiple sclerosis.PMID 19348623Read ↗

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A family with autosomal dominant leukodystrophy linked to 5q23.2-q23.3 without lamin B1 mutations.Semantic proximity Read ↗

Genomic duplications mediate overexpression of lamin B1 in adult-onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms.Semantic proximity Read ↗

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