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Article

[Polymorphism of tox and dtxR genes in circulating strains of Corynebacterium diphtheriae].

Zhurnal mikrobiologii, epidemiologii i immunobiologii - 1 Jan 2000

Kombarova S Iu, Borisova O Iu, Mel'nikov V G, Gubina N I, Loseva L V, Mazurova I K

Abstract excerpt

Polymorphism of tox and dtxR genes responsible for diphtheria toxin synthesis was revealed. Seven point mutations in tox gene were detected; study of their combinations allowed to determine 10 allelic variants of the tox gene in C. diphtheriae strains. Majority of mutations did not lead to changes in substitutions in amino acid sequence of diphtheria toxin. In tox gene from 2 strains of mitis biovar, ribotype...

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PMID: 19340963

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