Article
Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2009
Karlberg Susann, Lipsanen-Nyman Marita, Lassus Heini, Kallijärvi Jukka, Lehesjoki Anna-Elina, Butzow Ralf
Abstract excerpt
Mulibrey nanism is an autosomal recessive growth disorder caused by mutations in the TRIM37 gene encoding a protein of unknown function. More than half of female patients with Mulibrey nanism develop benign mesenchymal tumors of ovarian sex cord-stromal origin. In this work, we characterize the gynecological tumors of female patients with Mulibrey nanism in detail. In addition to tumors of the fibrothecoma group,...
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