Article
Study of the variability in upper and lower airway morphology in Sprague-Dawley rats using modern micro-CT scan-based segmentation techniques.
Anatomical record (Hoboken, N.J. : 2007) - 1 May 2009
De Backer Jan W, Vos Wim G, Burnell Patricia, Verhulst Stijn L, Salmon Phil, De Clerck Nora, De Backer Wilfried
Abstract excerpt
Animal models are being used extensively in pre-clinical and safety assessment studies to assess the effectiveness and safety of new chemical entities and delivery systems. Although never entirely replacing the need for animal testing, the use of computer simulations could eventually reduce the amount of animals needed for research purposes and refine the data acquired from the animal studies. Computational fluid...
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