Article
Differential susceptibility of adenovirus clinical isolates to cidofovir and ribavirin is not related to species alone.
Antiviral therapy - 1 Jan 2009
Morfin Florence, Dupuis-Girod Sophie, Frobert Emilie, Mundweiler Stéphanie, Carrington David, Sedlacek Petr, Bierings Mare, Cetkovsky Petr, Kroes Aloys C M, van Tol Maarten J D, Thouvenot Danielle
Abstract excerpt
BACKGROUND: We have previously reported that human adenovirus (HAdV) reference strains clearly show species-dependent resistance to ribavirin, whereas different species of HAdV are equally sensitive to cidofovir. All the serotypes tested were susceptible to cidofovir, whereas only serotypes from species C were sensitive to ribavirin. Here, we aimed to extend these investigations to clinical isolates. METHODS: In...
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