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Article

Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice.

Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - 1 Aug 2009

Pizzasegola Chiara, Caron Ilaria, Daleno Cristina, Ronchi Anna, Minoia Claudio, Carrì Maria Teresa, Bendotti Caterina

Abstract excerpt

It has been shown that chronic treatment with lithium carbonate (Li(2)CO(3)) in presymptomatic SOD1G93A transgenic male mice, a model of ALS, was able to remarkably increase their lifespan through the activation of autophagy and the promotion of mitochondriogenesis and neurogenesis. This prompted us to test the lithium effect also in female SOD1G93A mice with two phenotypes of different disease severity. Female...

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PMID: 19308767
DOI: 10.1080/17482960902803440

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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