Article
Kit and foxd3 genetically interact to regulate melanophore survival in zebrafish.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2009
Cooper Cynthia D, Linbo Tor H, Raible David W
Abstract excerpt
We have investigated the role of foxd3 activity in conjunction with signaling by the kit tyrosine kinase receptor in zebrafish black pigment cell (melanophore) development. As loss-of-function of these molecules individually has distinct effects on melanophore number, we have examined the phenotype of double mutants. Individuals with a null mutation in kit have fewer melanophores than wild-type, with cells lost...
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