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Article

Two-dimensional electrophoresis of tau mutants reveals specific phosphorylation pattern likely linked to early tau conformational changes.

PloS one - 1 Jan 2009

Bretteville Alexis, Ando Kunie, Ghestem Antoine, Loyens Anne, Bégard Séverine, Beauvillain Jean-Claude, Sergeant Nicolas, Hamdane Malika, Buée Luc

Abstract excerpt

The role of Tau phosphorylation in neurofibrillary degeneration linked to Alzheimer's disease remains to be established. While transgenic mice based on FTDP-17 Tau mutations recapitulate hallmarks of neurofibrillary degeneration, cell models could be helpful for exploratory studies on molecular mechanisms underlying Tau pathology. Here, "human neuronal cell lines" overexpressing Wild Type or mutated Tau were...

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Share to Cell Line, Tumor
Share to Electrophoresis, Gel, Two-Dimensional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19290042
DOI: 10.1371/journal.pone.0004843
PMCID: PMC2653646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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