Lessons from Fungal F-Box Proteins

Abstract excerpt

The F-box domain, so called after a conserved domain found in human cyclin F (5), was described in 1996 (6) after first being denoted a conserved N-terminal domain found in a subset of proteins (110). The F-box hypothesis was introduced shortly after (162, 185) and holds that F-box-containing proteins (henceforth F-box proteins) act as scavengers in the cell, collecting “junk” proteins to deliver to a “waste...

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