Article
Primary cultures of renal proximal tubule cells derived from individuals with primary hyperoxaluria.
Urological research - 1 Jun 2009
Price Karen L, Hulton Sally-Anne, van't Hoff William G, Masters John R, Rumsby Gill
Abstract excerpt
The primary hyperoxalurias, PH1 and PH2, are inherited disorders caused by deficiencies of alanine:glyoxylate aminotransferase and glyoxylate reductase, respectively. Mutations in either of these enzymes leads to endogenous oxalate overproduction primarily in the liver, but most pathological effects are exhibited in the kidney ultimately leading to end-stage renal failure and systemic oxalosis. To provide a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.