Article
The primary hyperoxalurias.
Kidney international - 1 Jun 2009
Hoppe Bernd, Beck Bodo B, Milliner Dawn S
Abstract excerpt
The primary hyperoxalurias (PHs) are rare disorders of glyoxylate metabolism in which specific hepatic enzyme deficiencies result in overproduction of oxalate. Due to the resulting severe hyperoxaluria, recurrent urolithiasis or progressive nephrocalcinosis are principal manifestations. End stage renal failure frequently occurs and is followed by systemic oxalate deposition along with its devastating effects. Due...
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