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Article

Primary hyperoxalurias: disorders of glyoxylate detoxification.

Biochimica et biophysica acta - 1 Sept 2012

Salido Eduardo, Pey Angel L, Rodriguez Rosa, Lorenzo Victor

Abstract excerpt

Glyoxylate detoxification is an important function of human peroxisomes. Glyoxylate is a highly reactive molecule, generated in the intermediary metabolism of glycine, hydroxyproline and glycolate mainly. Glyoxylate accumulation in the cytosol is readily transformed by lactate dehydrogenase into oxalate, a dicarboxylic acid that cannot be metabolized by mammals and forms tissue-damaging calcium oxalate crystals....

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Identifiers

PMID: 22446032
DOI: 10.1016/j.bbadis.2012.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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