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Article

Structural comparison of chromosomal and exogenous dihydrofolate reductase from Staphylococcus aureus in complex with the potent inhibitor trimethoprim.

Proteins - 15 Aug 2009

Heaslet Holly, Harris Melissa, Fahnoe Kelly, Sarver Ronald, Putz Henry, Chang Jeanne, Subramanyam Chakrapani, Barreiro Gabriela, Miller J Richard

Abstract excerpt

Dihydrofolate reductase (DHFR) is the enzyme responsible for the NADPH-dependent reduction of 5,6-dihydrofolate to 5,6,7,8-tetrahydrofolate, an essential cofactor in the synthesis of purines, thymidylate, methionine, and other key metabolites. Because of its importance in multiple cellular functions, DHFR has been the subject of much research targeting the enzyme with anticancer, antibacterial, and antimicrobial...

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Source

Identifiers

PMID: 19280600
DOI: 10.1002/prot.22383

Genes

DHFR
DAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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