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Article

Lack of Androgen Receptor Expression in Sertoli Cells Accounts for the Absence of Anti-Mullerian Hormone Repression during Early Human Testis Development

11 Mar 2009

Abstract excerpt

CONTEXT: Puberty is associated with increased testicular testosterone (TT) synthesis, which is required to trigger spermatogenesis and to repress anti-Mullerian hormone (AMH) production. However, testicular gonadotropin stimulation during fetal and newborn life neither initiates spermatogenesis nor represses AMH. OBJECTIVE: We postulated that a lack of androgen receptor (AR) expression in Sertoli cells (SC) might...

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PMID: 19276236
DOI: 10.1210/jc.2008-1909

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