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Article

Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu

4 Jun 2012

Abstract excerpt

BACKGROUND: In humans, as well as in other higher primates, the infantile testis is exposed to an adult-like hormonal milieu, but spermatogenesis is not initiated at this stage of primate development. In the present study, we examined the molecular basis of this intriguing infertile state of the primate testis. METHODS: The integrity of androgen receptor (AR) and FSH receptor (FSHR) signaling pathways in primary...

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Share to Hormonal and reproductive studies
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PMID: 22669085
DOI: 10.1093/humrep/des184

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