Article
The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study.
American journal of hypertension - 1 May 2009
Franceschini Nora, North Kari E, Arnett Donna, Pankow James S, Chung Jay H, Baird Lisa, Leppert Mark F, Eckfeldt John H, Boerwinkle Eric, Gu C Charles, Lewis Cora E, Myers Richard H, Turner Stephen T, Weder Alan, Kao W H Linda, Mosley Thomas H, Chakravarti Aravinda, Kramer Holly, Zhang Jinghui, Hunt Steven C
Abstract excerpt
BACKGROUND: Recent experimental evidence suggests that DNA damage and cell cycle regulatory proteins are involved in kidney injury and apoptosis. The checkpoint 2 gene (CHEK2) is an important transducer in DNA damage signaling pathways in response to injury, and therefore, CHEK2 variants may affect susceptibility to kidney disease. METHODS: We used tag-single-nucleotide polymorphisms (tag-SNPs) to evaluate the...
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