Article
Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populations.
Acta diabetologica - 1 Dec 2010
North Kari E, Franceschini Nora, Avery Christy L, Baird Lisa, Graff Mariaelisa, Leppert Mark, Chung Jay H, Zhang Jinghui, Hanis Craig, Boerwinkle Eric, Volcik Kelly A, Grove Megan L, Mosley Thomas H, Gu Charles, Heiss Gerardo, Pankow James S, Couper David J, Ballantyne Christie M, Linda Kao W H, Weder Alan B, Cooper Richard S, Ehret Georg B, O'Connor Ashley A, Chakravarti Aravinda, Hunt Steven C
Abstract excerpt
Identification and characterization of the genetic variants underlying type 2 diabetes susceptibility can provide important understanding of the etiology and pathogenesis of type 2 diabetes. We previously identified strong evidence of linkage for type 2 diabetes on chromosome 22 among 3,383 Hypertension Genetic Epidemiology Network (HyperGEN) participants from 1,124 families. The checkpoint 2 (CHEK2) gene, an...
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