The putative tumour modifier gene ATP5A1 is not mutated in human colorectal cancer cell lines but expression levels correlate with TP53 mutations and chromosomal instability.

Abstract excerpt

BACKGROUND: Both the putative modifier gene ATP5a1 and the tumour suppressor gene TP53 are involved in the regulation of apoptosis and may be involved in the development of colorectal cancers. AIMS: To investigate the relationship between these genes in 16 colorectal cancer cell lines. METHODS: Each gene was screened for mutation using high resolution melting analysis and sequencing. Expression of ATP5a1 mRNA was...

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