Article
Effect of robustness on selection of a mutation-rate regulating gene.
Physical review. E, Statistical, nonlinear, and soft matter physics - 1 Sept 2011
Ancliff Mark, Park Jeong-Man
Abstract excerpt
We study the evolution of a population of sequences, where each sequence is divided into a reproduction-rate (fitness) encoding part and a mutation-rate regulating part. Evolutionary selection acts on the sequence both by a direct fitness landscape and by indirect selection on a mutation landscape through which the sequence's mutation rate is determined, thereby providing a model of a mutation-rate-regulating...
Topics
- Animals
- Computer Simulation
- Evolution, Molecular
- Gene Expression Regulation
- Humans
- Models, Genetic
- Mutation
- Regulatory Sequences, Nucleic Acid
- Selection, Genetic