Article
No association of (-131C-->G) variant of CHI3L1 gene with risk of glioblastoma and prognosis.
Journal of neuro-oncology - 1 Sept 2009
Boisselier Blandine, Marie Yannick, El Hallani Soufiane, Kaloshi Gentian, Iershov Anton, Kavsan Vadym, Psimaras Dimitri, Thillet Joëlle, Hoang-Xuan Khe, Delattre Jean-Yves, Sanson Marc
Abstract excerpt
Expression of CHI3L1 (YKL-40) has been correlated with prognosis of glioblastoma. The variant allele (-131C-->G) of CHI3L1 promoter results in a lower transcription of CHI3L1. Therefore, we tested the hypothesis that the G variant could protect against the risk of gliomas or have a favorable prog...
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