The genetic basis of phenotypic adaptation I: fixation of beneficial mutations in the moving optimum model.

Abstract excerpt

We study the genetic basis of adaptation in a moving optimum model, in which the optimal value for a quantitative trait increases over time at a constant rate. We first analyze a one-locus two-allele model with recurrent mutation, for which we derive accurate analytical approximations for (i) the time at which a previously deleterious allele becomes beneficial, (ii) the waiting time for a successful new mutation,...

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